Skip to main content
. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Trends Endocrinol Metab. 2017 Aug 2;28(10):735–747. doi: 10.1016/j.tem.2017.07.002

Figure 1. Outline of sex determination and dosage compensation pathways.

Figure 1

The sex determination and dosage compensation pathways are outlined for Drosophila, human and C. elegans, with an emphasis on aspects that are similar between the species. Large ovals indicate X chromosomes, small ovals indicate Y chromosomes. Arrows indicate activation, T-bars indicate repression. Dashed arrows and T-bars indicate activation or repression of X chromosome gene expression by the respective dosage compensation machineries. The conserved doublesex-related gene is indicated in red font, and is involved in specification of male cell differentiation in each species. Please note that “Tra” in Drosophila is not homologous to “Tra” in C. elegans. Please see text for further details.