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Effects of mtDNA depletion on THP-1 cells. THP-1 cells were treated with 50 ng/mL EtBr for 8 weeks. A, Cell viability. B, Mitochondrial transcripts. C, Mitochondrial proteins relative to β-actin. D, Spectrophotometric measurements of isolated respiratory enzyme activity in cellular homogenates for complex IV (CIV) and citrate synthase (CS) activity. All experiments had 3 independent biological replicates and are presented as means ± SD. *P < .05 and **P < .01.
