Table E1.
Details of the 5 signaling pathways most significantly affected by transfection with TFAM siRNA
| Function | z-score | P-value | Genes with altered expression |
||
|---|---|---|---|---|---|
| Proportion of genes in pathway | Upregulated | Downregulated | |||
| Interferon signaling | |||||
| Cellular immune response Cytokine signaling |
−3.16 | 4.9 × 10−7 | 11/34 | — | IFI35, IFNB1, IFIT1, IFITM1, IFITM2, IFITM3, IFIT3, IRF9, OAS1, STAT2, STAT1 |
| TREM1 signaling | |||||
| Cellular immune response Cytokine response |
−3.50 | 7.9 × 10−7 | 16/75 | MPO | CCL3, CD83, CIITA, IL1B, ITGAX, MYD88, NLRC4, NLRP12, TLR1, TLR3, TLR6, TLR7, TNF, TREM1, TYROBP |
| Role of pattern recognition receptors in recognition of bacteria and viruses | |||||
| Cellular immune response Pathogen-influenced signaling |
−3.74 | 5.5 × 10−6 | 20/127 | IL12A | C3AR1, C5AR1, DDX58, EIF2AK2, IFIH1, IFNB1, IL1B, IRF7, MYD88, NLRC4, OAS1, OAS2, OAS3, PTX3, TLR1, TLR3, TLR6, TLR7, TNF |
| Toll-like receptor signaling | |||||
| Apoptosis Cellular immune response Humoral immune response Pathogen-influenced signaling |
−2.33 | 1.7 × 10−5 | 14/74 | IL12A, PPARA | EIF2AK2, FOS, IL1B, IL1RN, MYD88, NFKBIA, TLR1, TLR3, TLR6, TLR7, TNF, TNFAIP3 |
| Acute phase response | |||||
| Cytokine signaling | −2.67 | 5.2 × 10−3 | 17/169 | FTL, HMOX1, ORM1, ORM2, SOCS2 | A2M, AGT, CEBPB, FOS, IKBKE, IL1B, IL1RN, MYD88, NFKBIA, SERPINE1, SOCS3, TNF |