Table E2.
Details of the 5 pathways most significantly affected by the altered transcriptomic response to LPS following transfection with TFAM siRNA
| Function | z-score | P-value | Genes with altered expression |
||
|---|---|---|---|---|---|
| Proportion | Upregulated | Downregulated | |||
| TREM1 signaling | |||||
| Cellular immune response Cytokine response |
−4.15 | 6.3 × 10−9 | 21/75 | MPO | CCL2, CCL3, CD40, CD83, CIITA, ICAM1, IL1B, ITGAX, MYD88, NLRC4, NLRP12, NOD2, TLR1, TLR3, TLR4, TLR6, TLR7, TNF, TREM1, TYROBP |
| Toll-like receptor signaling | |||||
| Apoptosis Cellular immune response Humoral immune response Pathogen-influenced signaling |
−2.13 | 2.8 × 10−8 | 20/74 | ELK1, IL12A, MAP3K14, PPARA, TRAF4 | EIF2AK2, FOS, IL1B, IL1RN, IRAK2, JUN, MYD88, NFKBIA, TLR1, TLR3, TLR4, TLR6, TLR7, TNF, TNFAIP3 |
| Interferon signaling | |||||
| Cellular immune response Cytokine signaling |
−3.32 | 7.2 × 10−7 | 12/34 | — | IFI35, IFIT1, IFIT3, IFITM1, IFITM3, IFNB1, IRF9, MX1, OAS1, STAT2, STAT1, TAP1 |
| Activation of interferon regulatory factors by cytosolic pattern recognition receptors | |||||
| Cellular immune response | −2.00 | 2.1 × 10−6 | 12/34 | — | ADAR, CD40, DDX58, DHX58, IFIH1, IFIT2, IFNB1, IKBKE, IRF7, IRF9, ISG15, JUN, NFKBIA, STAT1, STAT2, TNF |
| Role of pattern recognition receptors in recognition of bacteria and viruses | |||||
| Cellular immune response Pathogen-influenced signaling |
−3.74 | 5.5 × 10−6 | 20/127 | IL12A | C3, C3AR1, C5AR1, DDX58, EIF2AK2, IFIH1, IFNB1, IL1B, IRF7, MYD88, NLRC4, NOD2, OAS1-3, PTX3, TLR1, TLR3, TLR4, TLR6, TLR7, TNF |