Table 3.
Causality and Severity Scores and Outcomes of African-American and Caucasians with definite, highly likely, or probable Drug-Induced Liver Injury
| Feature | African-Americans (n=144) | Caucasians (n=841) | P value |
|---|---|---|---|
|
| |||
| DILIN Causality Score (mean, SD) | 2.1 ± 0.7 | 2.0 ± 0.7 | 0.08 |
|
| |||
| DILIN Causality (%): Definite | 19 | 25 | |
| Highly likely | 53 | 53 | 0.20 |
| Probable | 28 | 23 | |
|
| |||
| DILIN Severity Score (mean, SD) | 3.0 ± 1.2 | 2.6 ± 1.2 | <0.001 |
|
| |||
| DILIN Severity (%) | |||
| Mild | 15 | 23 | |
| Moderate | 12 | 24 | <0.001 |
| Moderate-Hospitalized | 38 | 29 | |
| Severe | 24 | 18 | |
| Fatal (within 6 months of onset) | 10 | 6 | |
|
| |||
| Hospitalization or non-DILI hospitalization was prolonged (%) | 77 | 56 | <0.001 |
|
| |||
| Death, any cause (%) | 9.0 | 5.7 | 0.10 |
|
| |||
| DILI-related death or Liver Transplantation (%) | 10.2 | 5.8 | 0.16 |
|
| |||
| Chronicity (%) | 24 | 16 | 0.06 |
DILIN: Drug Induced Liver Injury Network; DILI: Drug Induced Liver Injury