Table 1.

Semi-quantitative scoring scheme used to assess histopathological changes in the large intestine after C. rodentium infection.

A – Epithelium
Score	Hyperplasia		Goblet cell depletion
0	None		None
1	Mild (1.5 × normal length)	AND/OR	Mild (25%)
2	Moderate (2–3 × normal length)		Moderate (25–50%)
3	Severe (>3 × normal length)		Severe (>50%)

B – Lamina propria inflammation
Score	Description
0	None – few leukocytes
1	Mild – some leukocytes at villi tips OR many lymphoid follicles
2	Moderate – marked infiltrate (crypt broadening)
3	Severe – dense leukocyte infiltrate

C – Area affected (% of section)
Score	Description
0	None
1	0–25%
2	25–50%
3	>50%

D – Severe markers
Score	Submucosal inflammation		Crypt abscesses		Crypt branching	Ulceration or Extensive fibrosis
0	None		0		No	No
1	Mild	OR	<5		No	No
2	Mild	AND	<5		No	No
2	Severe	OR	>5	OR	Yes	No
3	Severe	AND	>5	OR	Yes	No
3	–		–		–	Yes