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. Author manuscript; available in PMC: 2017 Nov 2.
Published in final edited form as: Cell Rep. 2017 Jul 11;20(2):491–504. doi: 10.1016/j.celrep.2017.06.060

Figure 4. Maternal peripartum exposure to cefoperazone induces persistent and significant changes in specific microbial oligotypes in IL-10 KO dams and offspring.

Figure 4

(A) Comprehensive comparison of gut microbes in fecal samples collected from non-treatment (NT) and cefoperazone (CPZ)-treated IL-10 KO dams at weaning (wk 3) and their offspring at 3, 7 and 11 wks. Oligotype abundance was determined in samples from dams and offspring that were tracked for spontaneous colitis or DSS-treated. Sixteen samples were excluded due to low number of sequences. Columns represent an individual oligotype and rows represent individual samples. Samples with red horizontal bars represent mice that developed spontaneous colitis (Spont. Colitis) or DSS-colitis following exposure at 23 wks of age and euthanized due to frank colitis. Colored bars at the bottom of the figure represent dominant phyla. (B) Significant changes in mean proportions of oligotypes between NT and CPZ offspring at 3, 7, and 11 wks of age determined by STAMP. The top 10 oligotypes with the greatest changes in relative abundance are presented as extended error bar plots (bars represent 95% confidence intervals). All oligotypes significantly different between groups are presented in the supplementary table. See Table S1. (C) Oligotypes with significant differences in relative abundance were identified at 3 and 11 wks of age between males from CPZ-exposed dams that did or did not develop spontaneous colitis. All oligotypes identified as significantly altered between groups are sorted by changes in relative abundance. See also Figure S4.