Defining a Cancer Dependency Map

. Author manuscript; available in PMC: 2018 Jul 27.

Published in final edited form as: Cell. 2017 Jul 27;170(3):564–576.e16. doi: 10.1016/j.cell.2017.06.010

	Features	Models predict
Mutation-driven dependencies	Hotspot mutations, Missense mutations, Copy number	One model predicts z-scored sensitivity. One model predicts z-scored sensitivity where values >−2 are replaced with zero
Expression-driven dependencies	Hotspot mutations, Missense mutations, Copy number, Gene expression	One model predicts z-scored sensitivity. One model predicts z-scored sensitivity where values >−2 are replaced with zero
CYCLOPS	Copy number, Gene expression	One model predicts z-scored sensitivity.
Paralog deficiency dependencies	Missense and damaging mutations, Copy number and Gene expression of all sequence paralog genes.	One model predicts z-scored sensitivity. One model predicts z-scored sensitivity where values >−2 are replaced with zero
Related	Missense and damaging mutations, Copy number and Gene expression of associated genes via PPI, CORUM or GenesLikeMe’s super-pathways.	One model predicts z-scored sensitivity. One model predicts z-scored sensitivity where values >−2 are replaced with zero