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. Author manuscript; available in PMC: 2018 Jan 11.

Published in final edited form as: Nat Biomed Eng. 2017 Jul 11;1:0096. doi: 10.1038/s41551-017-0096

Concentration-dependent inhibition of endothelial network formation by known vascular inhibitors, measured as percent change in network area, compared to vehicle controls. Sensitivity of HUVECs to inhibitors is compared between the synthetic, VBP+ and Matrigel systems (n = 3, n = 8–12 for DMSO and PBS controls. Negative changes in area represent disconnected networks, while positive changes in area represent thickened network structures. A 100% change in area represents complete network disruption or monolayer formation.). Data represents means and error bars represent standard deviations. The test was performed twice over the course of these studies. Inhibited samples (*, and dark-gray bars) have a p-value < 0.05 by One-way ANOVA followed by Dunnett’s multiple comparisons analysis compared to the DMSO/1× PBS control conditions depending on the vehicle of the inhibitor.

Concentration-dependent inhibition of endothelial network formation by known vascular inhibitors, measured as percent change in network area, compared to vehicle controls. Sensitivity of HUVECs to inhibitors is compared between the synthetic, VBP+ and Matrigel systems (n = 3, n = 8–12 for DMSO and PBS controls. Negative changes in area represent disconnected networks, while positive changes in area represent thickened network structures. A 100% change in area represents complete network disruption or monolayer formation.). Data represents means and error bars represent standard deviations. The test was performed twice over the course of these studies. Inhibited samples (*, and dark-gray bars) have a p-value < 0.05 by One-way ANOVA followed by Dunnett’s multiple comparisons analysis compared to the DMSO/1× PBS control conditions depending on the vehicle of the inhibitor.