Table 1. Physiological parameters and blood tests.
Parameters | Sham | Control | Control+Ex4 | DM | DM+Ex4 |
---|---|---|---|---|---|
Body mass gained (g)* | - | +2.1±23 | +11.1±9.9 | -27.5±11.5 | -18.0±7.5 |
Gastric pH | 4.1±0.5 | 3.3±1.2 | 3.3±0.5 | 3.0±0.9 | 2.9±0.5 |
Blood glucose (mg/dl)# | 166.2±33.9 | 153.5±22.5 | 121.5±12.1 | 329.6±125.5† | 381.0±104.0† |
Serum IL-6 (pg/ml) | 35.5±11.5 | 46.2±11.9 | - | 36.7±13.7 | 52.6±46 |
Serum MCP-1 (pg/ml) | 70.3±30.7 | 90.0±59.4 | - | 138.5±101.8 | 115.8±82.3 |
DM: diabetes mellitus; Ex4: exendin-4; IL-6: interleukin-6; MCP-1: monocyte chemotactic protein-1;
*Body mass (BM) change = BM at induction of peptic ulcer—BM at sacrifice.
#Blood glucose levels were measured at the end of experiment (at sacrifice).
†P< 0.05 compared with control (statistical analysis was performed with sham group). Serum concentrations of IL-6 and MCP-1 were not measured in control+Ex4 group. Data was analyzed by one-way ANOVA. n = 8–9 in control, control+Ex4, DM and DM+Ex4 groups, n = 4 in sham.