Table 1. Evaluation of markers of systemic immune activation as covariates on pyrazinamide clearance.

HIV disease marker evaluated as covariate on pyrazinamide clearance	Change in objective function value	Between subject variability of clearance
Base model*	-	21.3%
Percent CD38+HLADR+CD8+	5.91 **	17.5%
Log-IL6	0.09	21.2%
sCD14	1.22	21.1%
CD4+ T cell count	0.01	21.5%
Log HIV viral load	0.37	20.9%

*Includes the covariate effects of gender and weight on clearance.

**p = 0.015 under a chi-squared distribution with 1 degree of freedom