Table S1.

In vitro release kinetic parameters

Formulations	Medium	Zero-order		First-order		Higuchi		Weibull
		R2	AIC	R2	AIC	R2	AIC	R2	AIC	βa
Cur NLCs	Ab	0.9797	22.58	0.9823	30.23	0.9881	18.83	0.9973	9.94	1.239
	Bc	0.9648	30.99	0.9831	33.9	0.9831	25.14	0.9992	4.29	1.312
Cur-TCA20 NLCs	Ab	0.9948	18.63	0.9764	30.74	0.7671	49.05	0.999	9.4	1.227
	Bc	0.9887	34.43	0.9606	41.95	0.7676	58.63	0.9993	16.73	1.47
Cur-TCA50 NLCs	Ab	0.992	22.81	0.9708	33.16	0.7566	50.13	0.9993	7.76	1.191
	Bc	0.9929	30.68	0.9703	37.16	0.7635	58.67	0.9998	7.84	1.614
Cur-TCA100 NLCs	Ab	0.9971	12.17	0.9871	24.08	0.7872	46.5	0.9991	6.76	1.146
	Bc	0.9925	29.31	0.9882	28.67	0.7514	57.28	0.9995	11.48	1.628

Notes:

^aβ-exponent parameter in Weibull model.

^bA, in pH 1.2 HCI for 2 hours and pH 6.8 PBS for next 22 hours;

^cB, in physiological saline.

Abbreviations: AIC, Akaike information criterion; Cur, curcumin; NLCs, nanostructured lipid carriers; TCA, taurocholic acid.