Table 1.

Histopathology of all animals in the study detailing tumor incidence

Mouse	Week
	Week 17
1	Cancer in submucosa and muscle; deeply muscle invasive
2	Large tumor, cancer in submucosa, muscle thinned out but tumor non-muscle invasive
3	No tumor, in situ disease; confined to epithelium
4	Large muscle-invasive tumor
5	Lower graded lesion, cancer with no squamous differentiation, tumor does not reach muscle
	Week 20
1	High-grade tumor, does not reach muscle; muscle attenuated with submucosa expanded by tumor
2	Extensive squamous differentiation, tumor reaches outer surface of bladder extending all the way through the muscle
3	Highly inflamed, epithelium has large variable nuclei, dysplastic; however, no musle-invasive tumor
	Week 22
1	Extensive keratin and inflammation, tumor through bladder wall, profound inflammatory response
2	Tumor growing down and invading the muscle, tumor stays superficial in the muscle
3	No muscle-invasive tumor present