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. 2017 Nov 2;12(11):e0187081. doi: 10.1371/journal.pone.0187081

Table 1. Symptom distribution between different age groups.

  Group 1 (n = 59) Group 2
(n = 77)
Group 3
(n = 82)
Isolated gastrointestinal symptoms 17 (28.8%) 36 (46.8%) 52 (63.4%) p<0.001
Isolated extraesophageal symptoms 9 (15.3%) 14 (18.2%) 13 (15,9%)
Concomitant appearance of gastrointestinal and extraesophageal symptoms 33 (55.9%) 27 (35.1%) 17 (20.7%)
Gastrointestinal symptoms
    Vomiting/Regurgitation 49 (83%) 55 (71.4%) 34 (41.5%) p<0.001
    Heartburn 0 8 (10.4%) 35 (42.7%)
    Epigastric pain 1 (2%) 10 (13%) 27 (32.9%)
    Back arching 17 (28.8%) 6 (7.8%) 0
Respiratory symptoms
    Cough 26 (44.1%) 38 (49.4%) 25 (30.4%) p<0.001
    Apnea 17 (28.8%) 1 (1.3%) 0