Table 4. Gene expression in membranes, retinal tissues and cells, and blood.
| n = 11 | n = 10 | Relative expression | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Gene | iERM | PDR | iERM | PDR* | Retina | RPE | Glial cells | HRECs | HRPCs | Blood |
| ADIPOQ | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
| ANGPT2 | 7 | 9 | 30 | 135 | 150 | 0 | 4 | 22 | 0 | 13 |
| BDNF | 11 | 9 | 182 | 72 | 117 | 387 | 475 | 1337 | 550 | 1015 |
| bNGF | 8 | 6 | 7 | 32 | 13 | 394 | 134 | 30 | 210 | 687 |
| GDF15 | 11 | 10 | 35 | 48 | 9 | 14 | 80 | 34 | 411 | 487 |
| GDNF | 11 | 10 | 12962 | 41091 | 0 | 0 | 156 | 177 | 0 | 512 |
| HGF | 10 | 8 | 136 | 359 | 268 | 3 | 0 | 72 | 857 | 153 |
| ICAM1 | 11 | 9 | 90 | 224 | 780 | 545 | 24 | 279 | 75 | 1394 |
| IGFBP1 | 7 | 7 | 26 | 47 | 0 | 1 | 4 | 721 | 7 | 56 |
| IGFBP3 | 11 | 10 | 4179 | 2726 | 282 | 10095 | 317 | 3384 | 5234 | 257 |
| NCAM1 | 10 | 8 | 810 | 392 | 1006 | 11 | 176 | 241 | 0 | 19 |
| NGFR | 10 | 8 | 1295 | 1933 | 1302 | 0 | 27 | 0 | 0 | 0 |
| NOV | 4 | 5 | 5 | 10 | 38 | 151 | 0 | 10 | 5 | 163 |
| NRG1 | 10 | 5 | 36 | 12 | 47 | 99 | 649 | 318 | 33 | 17 |
| NRG2 | 7 | 6 | 26 | 18 | 69 | 1 | 189 | 5 | 2 | 0 |
| NRN1 | 11 | 9 | 288 | 392 | 3652 | 0 | 1628 | 169 | 0 | 979 |
| NTF3 | 4 | 4 | 9 | 6 | 36 | 940 | 19 | 80 | 0.2 | 711 |
| NTF4 | 0 | 0 | 0 | 0 | 0 | 0 | 101 | 3 | 5 | 773 |
| PDGFA | 0 | 2 | 0 | 4 | 0 | 0 | 11 | 0 | 0 | 17 |
| PDGFB | 0 | 0 | 0 | 0 | 0 | 0.5 | 3 | 14 | 0 | 29 |
| PGF | 9 | 7 | 242 | 47 | 71 | 0 | 10 | 15 | 0 | 5913 |
| THBS1 | 11 | 10 | 2479 | 2011 | 2 | 610 | 88481 | 2749 | 7989 | 1132 |
| TIMP1 | 11 | 10 | 6544 | 10088 | 11366 | 90200 | 40299 | 361760 | 59631 | 12807 |
| VEGFA | 11 | 10 | 4434 | 907 | 8879 | 18 | 8369 | 165 | 188 | 507 |
Left side (iERM, PDR): number of membranes in which gene expression is detected. Right side (Relative expression): abundance of gene expression in arbitrary units. iERM, idiopathic epiretinal membrane; PDR, epiretinal membrane from PDR patient; Retina, whole retina of non-diabetic donor eye; RPE, primary retinal pigment epithelial cells; Glial cells, U373 cell line; HRECs, human primary retinal endothelial cells; HRPCs, human primary retinal pericytes; Blood, pooled whole blood from patients with diabetic macular edema. Underlined values show significant difference in gene expression levels between PDR and iERM membranes (P < 0.05).