Table 3. Univariate and multivariate Cox regression analyses of factors associated with a second remission (Intensive therapy was tested as a time-dependent variable).
| Variables | Univariate Model | Multivariate Model | ||
|---|---|---|---|---|
| HR [95% CI] | P value | HR [95% CI] | P value | |
| Hypertension (kidney biopsy) | 0.99 [0.49–2.04] | 0.99 | ||
| IgA/C3 ratio≥ 3 (kidney biopsy) | 0.99 [0.49–2.00] | 0.98 | ||
| Age (per 10years.) | 0.97 [0.76–1.24] | 0.83 | ||
| Sex (male) | 1.04 [0.49–2.20] | 0.92 | ||
| Antecedent infection | 1.45 [0.65–3.24] | 0.36 | ||
| Usage of RASBs | 0.64 [0.32–1.27] | 0.20 | ||
| Usage of PSL | 1.04 [0.42–2.53] | 0.94 | ||
| MAP (per 10mmHg) | 1.17 [0.90–1.51] | 0.24 | ||
| TA-MAP (per 10mmHg) | 1.23 [0.84–1.82] | 0.29 | 1.29 [0.83–2.01] | 0.26 |
| eGFR≤ 60 ml/min/1.73m2 | 1.20 [0.57–2.54] | 0.63 | 1.08 [0.42–2.75] | 0.87 |
| UPE≥ 1g/gCr | 0.83 [0.41–1.67] | 0.60 | ||
| TA-P≥ 0.5g/gCr | 0.84 [0.42–1.66] | 0.62 | 0.81 [0.39–1.67] | 0.57 |
| U-RBC≥ 5/HPF | 1.07 [0.54–2.10] | 0.85 | 0.80 [0.37–1.74] | 0.57 |
| Remission duration (per 1 month) | 0.99 [0.98–1.01] | 0.54 | ||
| JHC Ⅱ+Ⅲ+Ⅳ | 0.99 [0.50–1.98] | 0.98 | 0.69 [0.33–1.45] | 0.33 |
| Season (autumn, winter) | 3.08 [1.26–7.52] | 0.013* | 3.51 [1.41–8.74] | 0.0069* |
| Mean outdoor temperature | 0.99 [0.95–1.04] | 0.75 | ||
| mean humidity (per 10%) | 1.03 [0.79–1.33] | 0.83 | ||
| Intensive therapy | 2.10 [1.03–4.27] | 0.042* | 2.26 [1.05–4.88] | 0.038* |
Abbreviations: HR, hazard ratio; CI, confidence interval; RASBs, renin-angiotensin system blockers; PSL, prednisolone; MAP, mean arterial pressure; TA-MAP, time-averaged mean arterial pressure; eGFR, estimated glomerular filtration rate; UPE, urinary protein excretion; TA-P, time-averaged proteinuria; U-RBC, urinary red blood cell sediments; HPF, high power field; HG, histological grade; JHC, Japanese histological classification
* p < 0.05