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. Author manuscript; available in PMC: 2017 Nov 2.
Published in final edited form as: J Am Chem Soc. 2016 Dec 15;138(51):16686–16695. doi: 10.1021/jacs.6b09538

Figure 2.

Figure 2

Preparation and characterization of ZnP@pyro. (A) Scheme showing the Zn-pyrophosphate core and the asymmetric lipid bilayer shell of ZnP@pyro. (B) TEM image showing the spherical and nearly monodispersed morphology of ZnP@pyro (scale bar = 200 nm). (C) Number-average diameter of ZnP@pyro in PBS, measured by DLS. (D) Blood concentration of pyrolipid over time after i.v. injection of ZnP@pyro at a pyrolipid dose of 6 mg/kg. (E) Biodistribution and tumor uptake of ZnP@pyro in 4T1 tumor-bearing mice. Data are expressed as means ± s.d. (n = 3).