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. Author manuscript; available in PMC: 2017 Nov 2.
Published in final edited form as: Vitam Horm. 2016 Nov 29;104:113–131. doi: 10.1016/bs.vh.2016.10.002

Fig. 4.

Fig. 4

(A) Upon initially encountering a target organ, NGF concentrations are low and NGF-induced genes are not yet expressed. This marks a “transition window,” in which low NGF availability enhances axon growth and branching via PI3K signaling. (B) High NGF induces Coronin-1a expression, and PI3K signaling is dampened. Axon growth and branching slows.