Figure 7. Silencing HO-1 gene expression sensitized SAHA to induce tumor suppression in a xenograft mouse model.

(A, B) We subcutaneously inoculated NOD/SCID mice in both flanks with LY-10 cells (1×10⁷ cells) to establish a xenograft mouse model of DLBCL. Mice were treated every day with 50 mg/kg SAHA when tumors were palpable (day 12). This model was euthanized on the 14th day after treatment with SAHA. Tumor weights and volumes were measured and calculated. (C) We used a ruler to measure sizes and weights of spleens from this model. Data are representative of three independent experiments. *P<0.05, **P<0.01.