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. 2017 Jul 28;8(45):78496–78506. doi: 10.18632/oncotarget.19655

Figure 5. TIPE1 inhibited tumorigenesis in vivo.

Figure 5

(A) Ten BALB/c nude mice were randomly divided into two groups (5 mice per group) and subjected to injection with A549-Ctrl and A549-TIPE1 cancer cells. Representative tumors were imaged after sacrifice to visually assess tumor growth. (B) The average tumor volume in each group (n=5) is shown as a function of time (**, p<0.01; ***, p<0.001, compared with Ctrl group). (C) tumor weight in each group (n=5) is shown (**, p<0.01, compared with Ctrl group). (D and E) IHC for analysis of TIPE1 and PCNA protein expression in Ctrl and TIPE1 A549 tumor tissues. Percentage of positive cells were analyzed (n=5). (F) TUNEL for analysis of apoptosis cells in Ctrl and TIPE1 A549 tumor tissues. Percentage of apoptosis cells were analyzed (n=5).