Figure 5. Low expression of RGS4 increases melanoma cell migration and invasion.

(A to D) Migration and invasion assays were performed using A375 cell transfected with siRGS4 and corresponding si-NC, respectively. (E and F) The effect of RGS4 down-regulation on the expression of MMP2,MMP9, E-cadherin and N-cadherin was examined by Western blot. Error bars indicate ± SD. *p < 0.05; **p < 0.01 by Student’s t-test. All the results were repeated thrice.