Table 2. Uni- and multivariate analyses of prognostic factors influencing cancer-specific survival (CSS) in clear-cell RCC.

	Univariate		Multivariate
	M0 + M1				M0		M1
	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
Grade of malignancy1	4.46 (3.20–6.21)	< 0.001	1.88 (1.27–2.78)	0.002	2.17 (1.28–3.71)	0.004	1.62 (0.94–2.77)	0.0798
Tumor extent2	3.63 (2.64–4.98)	< 0.001	2.12 (1.49- 3.03)	< 0.001	2.59 (1.65–4.07)	< 0.001	1.28 (0.72–2.26)	0.3956
Lymphnode metastasis3	5.06 (3.33–7.69)	< 0.001	1.39 (0.87–2.23)	0.169	2.57 (1.32–4.99)	0.005	1.08 (0.57–2.04)	0.8206
Distant metastasis4	11.58 (8.34–16.08)	< 0.001	6.68 (4.62–9.67)	< 0.001	-	-	-	-
ECOG5	2.15 (1.58–2.93)	< 0.001	1.56 (1.13–2.16)	0.007	1.67 (1.09–2.57)	0.018	1.20 (0.72–1.99)	0.4798
Sex6	0.69 (0.50–0.95)	0.025	0.76 (0.55–1.06)	0.103	0.76 (0.50–1.17)	0.219	0.80 (0.48–1.35)	0.4034
AR-Expression7	0.54 (0.38–0.76)	< 0.001	0.65 (0.46–0.92)	0.017	0.62 (0.39–0.98)	0.040	0.84 (0.49–1.44)	0.5180

¹G3 vs G1/G2.

²pT3/pT4 vs pT1/pT2.

³pN1/pN2 vs N0/pN0.

⁴M1 vs M0.

⁵0 vs ≥ 1.

⁶Female vs Male.

⁷> 5 vs ≤ 5 (%).

HR, hazard ratio; CI, confidence interval. Probability values and hazard ratios considered statistically significant are shown in bold.