Table 1. Univariate and multivariate analysis of prognostic factors for OS and DFS of CRC patients.
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CIa) |
P | HR (95% CI) |
P | |
|
OS (n=240) | ||||
| Histology (Not well/Well) |
1.29 (0.81-2.02) |
0.28 | ||
| Tumor size (≧5cm/<5cm) |
1.59 (1.01-2.50) |
0.04 | 1.22 (0.76-1.97) |
0.42 |
| Depth of invasion (≧SSc/≦MPb) |
2.58 (1.47-4.91) |
<0.01 | 1.10 (0.54-2.37) |
0.79 |
| Venous invasion (+/-) |
3.12 (1.82-5.71) |
<0.01 | 1.71 (1.88-3.46) |
0.11 |
| Lymphatic invasion (+/-) |
2.60 (1.66-4.11) |
<0.01 | 1.60 (0.95-2.70) |
0.08 |
| Lymph node metastasis (+/-) |
2.06 (1.31-3.27) |
<0.01 | 1.02 (0.61-1.71) |
0.94 |
| Liver matastasis (+/-) |
11.54 (7.07-18.89) |
<0.01 | 5.59 (3.04-10.53) |
<0.01 |
| Peritoneal dissemination (+/-) |
3.11 (1.37-6.18) |
<0.01 | 2.79 (1.16-5.97) |
0.02 |
| Serum CEA (≧5.0ng/ml/<5.0ng/ml) |
4.56 (2.78-7.79) |
<0.01 | 1.97 (1.07-3.70) |
0.03 |
| Serum CA19-9 (≧37U/ml/<37U/ml) |
3.41 (2.16-5.37) |
<0.01 | 0.99 (0.58-1.71) |
0.98 |
| Exosomal miR-203 in serum (high/low) |
3.53 (2.15-6.02) |
<0.01 | 2.27 (1.31-4.09) |
<0.01 |
|
DFS (n=170) | ||||
| Histology (Not well/Well) |
1.13 (0.56-2.22) |
0.73 | ||
| Tumor size (≧5cm/<5cm) |
0.81 (0.39-1.62) |
0.56 | ||
| Depth of invasion (≧SS/≦MP) |
1.47 (0.72-3.23) |
0.30 | ||
| Venous invasion (+/-) |
2.98 (1.41-7.07) |
<0.01 | 2.65 (1.24-6.33) |
0.01 |
| Lymphatic invasion (+/-) |
1.74 (0.85-3.44) |
0.13 | ||
| Lymph node metastasis (+/-) |
2.72 (1.38-5.59) |
<0.01 | 1.67 (0.83-3.50) |
0.15 |
| Serum CEA (≧5.0ng/ml/<5.0ng/ml) |
2.27 (1.15-4.48) |
0.02 | 2.14 (1.07-4.31) |
0.03 |
| Serum CA19-9 (≧37U/ml/<37U/ml) |
0.89 (0.30-2.11) |
0.81 | ||
| Exosomal miR-203 in serum (high/low) |
4.24 (2.05-9.62) |
<0.01 | 3.56 (1.70-8.16) |
<0.01 |
aCI, confidence interval; bMP, muscularis propria; cSS, subserosa.