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. 2017 Aug 10;8(45):78660–78676. doi: 10.18632/oncotarget.20205

Figure 1. AGEs increased FN and SphK1 protein expression and SphK1 activity in a time- and dose-dependent manner in GMCs.

Figure 1

The effects of AGEs with different times (150 μg/mL) (A) and different concentrations (24 h) (B) on the expression of FN and RAGE were determined by western blot assay. AGEs increased the protein expression of SphK1 in a time-(C) and dose-(D) dependent manner in GMCs. AGEs increased the activity of SphK1 in a time-(E) and dose-(F) dependent manner in GMCs. * P < 0.05, ** P < 0.01 vs. 0 μg/mL or 0 h for FN, RAGE and SphK1.