Table 1. Association between RASSF7 expression and clinicopathologic factors in NSCLC.
Characteristics | N | Overall expression | Cytoplasmic expression | Nuclear expression | ||||||
---|---|---|---|---|---|---|---|---|---|---|
low | high | P | low | high | P | low | high | P | ||
Age | ||||||||||
< 60 (years) | 35 | 8 | 27 | 0.706 | 10 | 25 | 0.595 | 31 | 4 | 0.210 |
≥ 60 (years) | 53 | 14 | 39 | 18 | 35 | 51 | 2 | |||
Gender | ||||||||||
Male | 34 | 10 | 24 | 0.448 | 9 | 25 | 0.393 | 31 | 3 | 0.673 |
Female | 54 | 12 | 42 | 19 | 35 | 51 | 3 | |||
Histology | ||||||||||
Squamous carcinoma | 35 | 6 | 29 | 0.167 | 16 | 37 | 0.686 | 32 | 3 | 0.679 |
Adenocarcinoma | 53 | 16 | 37 | 12 | 23 | 50 | 3 | |||
Differentiation | ||||||||||
Well | 30 | 9 | 21 | 0.436 | 9 | 21 | 0.792 | 29 | 1 | 0.659 |
Moderate/poor | 58 | 13 | 45 | 19 | 39 | 53 | 5 | |||
TNM stage | ||||||||||
I+ II | 34 | 15 | 19 | 0.001 | 19 | 15 | <0.001 | 34 | 0 | 0.078 |
III | 54 | 7 | 47 | 9 | 45 | 48 | 6 | |||
Lymph node metastasis | ||||||||||
Yes | 19 | 11 | 8 | <0.001* | 13 | 6 | <0.001 | 18 | 1 | 1.000 |
No | 69 | 11 | 58 | 15 | 54 | 64 | 5 |
RASSF7, Ras-association domain family 7; TNM, tumor-node-metastasis.