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. 2017 Sep 5;8(45):78948–78964. doi: 10.18632/oncotarget.20695

Figure 7. Recurrent BRLF1 expression leads to significant accumulation of genomic instability.

Figure 7

(A) Representative illustration of recurrent EBV BRLF1 expression in NPC cells. (B) The cells were harvested at passages 1, 5, 10 and 15 and subjected to micronucleus formation assay. Data are presented as means ± SD. P < 0.01, compared to TW01-TetER P1. (C) The genomic DNA of cells with mock or Dox treatment at passages 1 and 15 was extracted and subjected to aCGH. TW01-TetER (P1) was used as a common reference. The locations of amplifications and deletions are displayed to the right side of chromosomes with cytobands. Red and green colors indicate amplification and deletion, respectively.