Table 1. The surgical specimens and the biopsies studied along with the of IGF-IEc expression (%).

NEN type	N	Ki-67 (%)	Specimens	IGF-IEc expression (%)
Appendiceal NEN (N=3)	1	1	Surgical Specimen	0
	1	2	Surgical Specimen	0
	1	3	Lymph node	0
Colonic NEN	1	2	Surgical Specimen	0
Gallbladder NEN	1	6	Surgical Specimen	0
Gastric NEN (N=8)	3	2	Surgical Specimen	0
	1	5	Surgical specimen	0
	1	85	Surgical Specimen	0
	1	5	Surgical Specimen	10
	1	2	Surgical Specimen	50
	1	2	Surgical Specimen	100
Rectosigmoidal NEN (N=1)	1	50	Surgical Specimen	0
Pancreatic NEN (N=17)	1	1	Surgical Specimen	0
	1	6,50	Surgical Specimen	0
	2	7	Surgical Specimen	0
	1	17	Surgical Specimen	0
	1	50	Surgical Specimen	0
	1	55	Liver biopsy	0
	1	2	Surgical Specimen	1
	1	2.5	Surgical Specimen	1
	1	80	Liver biopsy	1
	1	2	Surgical Specimen	10
	1	3	Surgical Specimen	10
	1	6	Liver biopsy	10
	1	20	Liver biopsy	10
	1	15	Liver biopsy	50
	1	60	Liver biopsy	80
	1	6	Liver biopsy	100
Small bowel NEN (N=9)	2	1	Surgical Specimen	0
	3	1	Liver biopsy	0
	1	2	Surgical Specimen	1
	1	5	Surgical Specimen	1
	1	1,5	Liver biopsy	10
	1	5	Surgical Specimen	10
Lung NEC (N=2)	1	50	Surgical Specimen	0
	1	70	Lymph node	50
Uterine cervical NEC	1	70	Surgical Specimen	10
Undifferentiated NEC (Small cell) UPO	1	25	Bone marrow metastasis	1
	1	80	Lymph node	10
Undifferentiated NEC (Large cells) UPO	1	70	Lymph node	50
	1	70	Metastasis mediastinum	100
Total	47	5 (1-85)	Origin from primary tumors (30)/ metastases (17)	10 (1-100)

NEN: neuroendocrine neoplasm; NEC: neuroendocrine carcinoma; UPO: unknown primary origin.