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. 2017 Sep 8;8(45):79023–79033. doi: 10.18632/oncotarget.20784

Figure 6. Overexpression of miR-26b reverses cisplatin resistance of Hep-2/R in vivo.

Figure 6

(A) Mice were inoculated with miR-26b-overexpressed or control Hep-2/R cells. Subsequently, they were received cisplatin treatment with equal dose (2 mg/kg). The final xenografts were separated and weighted. *P<0.05 vs. LV-control group. #P<0.05 vs. Cisplatin+LV-control group. (B) Cells from xenografts were purified by using collagenase type III. Phosphorylation of ATF2 in these cells was evaluated by western blot analsyis. (C) Interaction with ATF2 and c-Jun in xenograft was evaluated by co-immunoprecipitation assays. (D) Expression of Bcl-xl in xenograft was evaluated by western blot analsyis.