Table 2. Differences between pre- and postoperative pituitary hormone levels in all patients1.
| Hormone | NFPA | Preoperative | Postoperative Day 1 | Postoperative Day 7 | Postoperative Month 4 | P |
|---|---|---|---|---|---|---|
| GH, ng/mL | No (n=34) | 6.8 ± 2.0 (1 ± 0) | 5.1 ± 2.0 (0.75 ± 0.01) | 2.5 ± 0.9 (0.37 ± 0) | 1.7 ± 0.6 (0.25 ± 0)a | <0.001 |
| Yes (n=47) | 1.2 ± 0.4 (1 ± 0) | 0.7 ± 0.1 (0.58 ± 0.01) | 0.6 ± 0.2 (0.50 ± 0) | 0.8 ± 0.2 (0.67 ± 0.01) | 0.314 | |
| ACTH, ng/mL | No (n=34) | 23.0 ± 5.0 (1 ± 0) | 17.9 ± 4.2 (0.78 ± 0.01) | 17.6 ± 2.1 (0.77 ± 0.01) | 23.5 ± 2.8 (1.02 ± 0.01) | 0.138 |
| Yes (n=47) | 21.0 ± 2.7 (1 ± 0) | 15.9 ± 3.6 (0.76 ± 0.01)a | 18.0 ± 3.6 (0.86 ± 0.01) | 23.2 ± 2.9 (1.10 ± 0.01)b | 0.004 | |
| TSH, ng/mL | No (n=34) | 1.5 ± 0.2 (1 ± 0) | 0.8 ± 0.1 (0.53 ± 0.01)a | 1.3 ± 0.3 (0.87 ± 0.01) | 1.5 ± 0.2 (1.00 ± 0.01)b | <0.001 |
| Yes (n=47) | 2.0 ± 0.3 (1 ± 0) | 1.2 ± 0.4 (0.60 ± 0.01) | 1.2 ± 0.1 (0.60 ± 0.01)a | 2.1 ± 0.2 (1.05 ± 0.01)c | <0.001 | |
| PRL, ng/mL | No (n=34) | 459.4 ± 147.9 (1 ± 0) | 183.0 ± 67.1 (0.40 ± 0.01)a | 182.2 ± 68.6 (0.40 ± 0.01)a | 180.2 ± 64.5 (0.39 ± 0.01)a | <0.001 |
| Yes (n=47) | 23.2 ± 3.5 (1 ± 0) | 7.9 ± 1.0 (0.34 ± 0)a | 8.0 ± 0.8 (0.34 ± 0)a | 9.4 ± 1.0 (0.41 ± 0)a,b | <0.001 | |
| FSH, ng/mL | No (n=34) | 4.3 ± 0.4 (1 ± 0) | 3.7 ± 0.4 (0.86 ± 0.01) | 3.6 ± 0.4 (0.84 ± 0.01) | 4.7 ± 0.5 (1.09 ± 0.01)b,c | 0.001 |
| Yes (n=47) | 19.2 ± 4.2 (1 ± 0) | 11.3 ± 2.1 (0.56 ± 0.01)a | 11.4 ± 2.2 (0.59 ± 0.01)a | 14.9 ± 3.0 (0.78 ± 0.01)b,c | <0.001 | |
| LH, ng/mL | No (n=34) | 3.2 ± 0.5 (1 ± 0) | 2.2 ± 0.4 (0.69 ± 0.01)a | 2.6 ± 0.4 (0.81 ± 0.01) | 4.4 ± 0.9 (1.38 ± 0.02)b | 0.006 |
| Yes (n=47) | 5.8 ± 1.2 (1 ± 0) | 4.4 ± 1.0 (0.76 ± 0.01)a | 4.4 ± 0.9 (0.76 ± 0.01)a | 6.8 ± 1.2 (1.17 ± 0.01)b,c | <0.001 | |
| Total hormone index2 | No (n=34) | 6.0 ± 0 | 4.0± 0.01 | 4.1 ± 0.01 | 5.1 ± 0.01 | <0.001 |
| Yes (n=47) | 6.0 ± 0 | 3.6± 0.01 | 3.7 ± 0.01 | 5.2. ±0.01 | <0.001 |
Data are presented as estimated mean ± standard error of mean (SEM) by generalized estimation equation and (mean ratio to preoperative measurement ± SEM). When a SEM of 0 is shown, it means the SEM is very small and approximates to 0.
Abbreviations: GH: growth hormone; ACTH: adrenocorticotropic hormone; TSH: thyroid-stimulating hormone; PRL: prolactin; FSH: follicle-stimulating hormone; LH: luteinizing hormone; NA: not available; NFPA: non-functioning pituitary adenomas.
1 Log2 or Log10 transformation was applied.
2 Total hormone index is equal to the sum of ratios of postoperative hormone levels to preoperative hormone levels.
a. Significant difference between the given time point and pre-operation, P < 0.05.
b. Significant difference between the given time point and Day 1, P < 0.05.
c. Significant difference between the given time point and Day 7, P < 0.05.