Table 2A. Drug-related adverse events by maximum grade per patient (N = 28).
Adverse Event | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 3/4 (%) |
---|---|---|---|---|---|
Hematology | |||||
Lymphocytopenia | 10 (36%) | 3 (11%) | 6 (21%) | 0 | 21% |
White Blood Count | 8 (29%) | 7 (25%) | 7 (25%) | 1 (4%) | 29% |
Neutropenia | 1 (4%) | 7 (25%) | 8 (29%) | 2 (7%) | 36% |
Thrombocytopenia | 14 (50%) | 3 (11%) | 0 | 3 (11%) | 11% |
Anemia | 9 (32%) | 10 (36%) | 3 (11%) | 0 | 11% |
Gastrointestinal disorders | |||||
Nausea | 11 (39%) | 1 (4%) | 0 | 0 | 0% |
Vomiting | 3 (11%) | 1 (4%) | 0 | 0 | 0% |
Gastroesophageal reflux disease | 4 (14%) | 0 | 0 | 0 | 0% |
Constipation | 2 (7%) | 0 | 0 | 0 | 0% |
Diarrhea | 2 (7%) | 0 | 0 | 0 | 0% |
Chemistry | |||||
Hyponatremia | 3 (11%) | 0 | 1 (4%) | 0 | 4% |
Hypomagnesemia | 1 (4%) | 0 | 0 | 0 | 0% |
Increased AST | 4 (14%) | 1 (4%) | 1 (4%) | 0 | 4% |
Increased ALT | 4 (14%) | 0 | 0 | 0 | 0% |
Other | |||||
Fatigue | 8 (29%) | 5 (18%) | 0 | 0 | 0% |
Carboplatin allergic reaction | 0 | 0 | 0 | 0 | 0% |
Skin rash | 3 (11%) | 1 (4%) | 0 | 0 | 0% |
Weight Loss | 1 (4%) | 0 | 0 | 0 | 0% |
Headache | 5 (18%) | 0 | 0 | 0 | 0% |