Table 3. Total health state costs and utility scores per year.

Cost input parameters	Estimate	Standard Error	Distribution	Source
Health state costs (per year)
Disease Free Survival, first year	€12,776	€798.14	Gamma	Cohort
Disease Free Survival, > first year	€1,237	€107.49	Gamma	Cohort
Local recurrence, first year	€12,777	€2,203.85	Gamma	Cohort
Local recurrence, > first year	€14,149	€4,679.22	Gamma	Cohort
Distant Metastases, first year	€30,165	€2,339.46	Gamma	Cohort
Distant Metastases, > first year	€47,959	€13,877.79	Gamma	Cohort
Cardiac Monitoring, first year	€467	€18.90	Gamma	Cohort
Trastuzumab # vials 150 mg per cycle	3	0.050	Gamma	Cohort
Trastuzumab # administrations	15	0.420	Gamma	Cohort
Trastuzumab cost / vial 150 mg	€605	-	Fixed
Costs of administration (day care)	€257	-	Fixed

Health state utility scores	Estimate	Standard Error	Distribution	Source
Disease free survival, first year	0.728	0.016	Beta	Cohort
Disease free survival, > first year	0.805	0.021	Beta	Cohort
Local recurrence, first year	0.725	0.021	Beta	Cohort
Local recurrence, > first year	0.708	0.088	Beta	Cohort
Distant metastases, first year	0.584	0.063	Beta	Cohort
Distant metastases, > first year	0.604	0.046	Beta	Cohort
Cardiac toxicity	0.600	0.010	Beta	[19]
Disutility	0.128	0.019

*treatment costs were assumed to be fixed since differences in these costs are most likely a result of variability (not parameter uncertainty)