Table 5. Univariate and multivariable Cox-proprotional Hazard model of postoperative variables predicting biochemical recurrence following radical prostatectomy.
| Variable | Univariate analyses | Multivariable analyses | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | |
| PSA, ng/mL (continuous) | 1.051 | 1.02-1.08 | 0.001 | n/a | ||
| PHI (continuous) | 1.007 | 1.003-1.011 | <0.001 | n/a | ||
| PHI >median vs <median |
1.83 | 1.16-2.89 | 0.009 | 1.57 | 0.98-2.49 | 0.060 |
| Pathological stage ≥pT3a vs <pT3a |
2.76 | 1.76-4.31 | <0.0001 | 1.76 | 1.11-2.80 | 0.017 |
| Margin status R1 vs R0 | 2.55 | 1.63-3.99 | <0.0001 | 1.50 | 0.92-2.44 | 0.101 |
| Age, yrs (continuous) | 1.03 | 0.99-1.07 | 0.167 | n/a | ||
| Pathological Gleason Score <7 (ISUP grade 1) =7 (ISUP grade 2 and 3) >7 (ISUP grade ≥4) |
Ref 2.06 5.40 |
1.15-3.67 2.91-10.13 |
0.015 <0.0001 |
Ref 1.92 3.73 |
1.09-3.40 1.94-7.14 |
0.025 <0.0001 |
Abbreviations: PSA – prostate-specific antigen; PHI – prostate health index; pT – pathological tumor stage; TRUS – transrectal ultrasound; CI – confidence interval; HR – hazard ratio; CI - confidence interval.