Table 3. Univariate and multivariate analysis of factors influencing relapse.
| Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR(95%CI) | P value | HR(95%CI) | P value | |
| Gender | 0.992(0.367-2.681) | 0.987 | ||
| Age at diagnosis | 2.735(0.888-8.426) | 0.08 | ||
| Bone pain | 1.016(0.358-2.884) | 0.976 | ||
| White blood cell count | 1.119(0.256-4.893) | 0.882 | ||
| T Lineage | 21.686(0.001-373971.584) | 0.536 | ||
| High risk group | 2.962(1.088-8.062) | 0.034 | 3.824(1.373-10.645) | 0.01 |
| BCR-ABL (+) | 20.709(0.000-4.718*10^9) | 0.758 | ||
| TP1 MRD | 1.368(0.482-3.886) | 0.556 | ||
| TP2 MRD | 21.872(0.002-254144.653) | 0.518 | ||
| Abnormal SPECT scan | 2.839(1.049-7.686) | 0.04 | 3.547(1.284-9.802) | 0.015 |
MRD: minimal residual disease; TP1: time point 1, at the end of remission induction around day 33;TP2: time point 2, before consolidation therapy ( in week 12)