Table 5. Univariate and multivariate analyses for prognostic factors in NSCLC patients with bone metastases (N = 140).
| Variables | OS (univariate) | P value | OS (multivariate) | P value |
|---|---|---|---|---|
| Hazard ratio (95% CI) | Hazard ratio (95% CI) | |||
| Age | 1.036 | 0.850 | 1.124 | 0.554 |
| (≤ 57.1vs. > 57.1) | (0.722–1.486) | (0.763–1.655) | ||
| Gender | 0.970 | 0.870 | 0.657 | 0.095 |
| (male vs. female) | (0.671–1.402) | (0.401–1.076) | ||
| ECOG PS | 3.115 | 0.004 | 4.053 | 0.001 |
| (0–1 vs. 2) | (1.429–6.790) | (1.799–9.127) | ||
| Smoking history | 0.937 | 0.730 | 0.679 | 0.131 |
| (yes vs. no) | (0.647–1.357) | (0.411–1.122) | ||
| N phase | 1.862 | 0.026 | 1.565 | 0.132 |
| (N0+N1 vs. N2+N3) | (1.077–3.217) | (0.874–2.802) | ||
| Number of bone metastases | 2.088 | 0.001 | 1.904 | 0.004 |
| (solitary vs. multiple) | (1.379–3.161) | (1.227–2.954) | ||
| Metastatic pattern | 1.297 | 0.009 | 1.283 | 0.022 |
| (isolated bone vs. bone and other organs) | (1.066–1.578) | (1.036–1.588) | ||
| Serum DKK1 levels | 1.648 | 0.026 | 1.675 | 0.029 |
| (low vs. high) | (1.060–2.561) | (1.055–2.660) |
Abbreviations: NSCLC, non-small cell lung cancer; OS, overall survival; ECOG PS, Eastern Cooperative Oncology Group performance status; CI, confidence interval; DKK1, Dickkopf-1.