Table 3. Haplotype frequencies and their association with OA risk in case and control subjects.
Frequency | Without adjustment | With adjustment | |||||
---|---|---|---|---|---|---|---|
SNPs | Haplotype | case | control | OR(95% CI) | Pa | OR(95% CI) | Pb |
rs639752/rs650108/rs520540 | CGATATGT | 0.395 | 0.360 | 1[Ref] | --- | 1[Ref] | --- |
/rs646910/rs602128/rs679620 | AAGTGCCC | 0.345 | 0.352 | 0.90 (0.60 - 1.35) | 0.61 | 0.77 (0.46 - 1.31) | 0.33 |
/rs678815/rs522616 | AAGTGCCT | 0.175 | 0.199 | 0.81 (0.49 - 1.34) | 0.41 | 0.72 (0.37 - 1.43) | 0.35 |
AGGAGCCT | 0.075 | 0.089 | 0.78 (0.40 - 1.53) | 0.47 | 0.47 (0.19 - 1.16) | 0.10 |
OR: odd ratio; CI: confidence interval.
P-value <0.05 indicates statistical significance.
P a values were calculated from two-side Chi-square tests.
P b values were calculated by unconditional logistic regression adjusted for age.