Table 3. High-dose versus standard-dose radiotherapy for ESCC.
| References | Radiation dose | Radiation technique | n | LC | P value | OS | P value |
|---|---|---|---|---|---|---|---|
| Minsky et al.[7] | 50.4 Gy | Conventional RT | 109 | 46% | > 0.05 | 40% (2 year) | > 0.05 |
| 64.8 Gy | 109 | 48% | 31% | ||||
| Zhang et al. [16] | < 51 Gy | Conventional RT | 43 | 19% | 0.011 | 3% (3year) | 0.054 |
| ≥ 51 Gy | 26 | 36% | 13% | ||||
| Hurmuzlu et al. [17] | ≥ 60 Gy | Conventional RT | 46 | 33 months (MST) | – | 22% (2 year) | – |
| Wang et al. [18] | < 50 Gy | Conventional RT | 11 | 47.7% (whole | 0.001 | 0% (5 year) | 0.002 |
| > 50 Gy | or 3D-CRT | 24 | group) | 29% | |||
| Suh et al. [19] | < 60 Gy | Conventional RT | 49 | 32% | < 0.01 | 18 mons (MST) | 0.26 |
| ≥ 60 Gy | 77 | 69% | 28 mons | ||||
| He et al. [20] | ≤ 50.4 Gy | 3D-CRT | 137 | 34.3% (LFR) | 0.024 | 33.0% (5 year) | 0.617 |
| > 50.4 Gy | 56 | 17.9% | 41.7% | ||||
| Kim et al. [21] | < 60 Gy | 3D-RT or IMRT | 120 | 37.3% | 0.02 | 22.3 mons (MST) | 0.043 |
| ≥ 60 Gy | 116 | 59.7% | 35.1 mons |
Abbreviations: LC, local control; RT, radiotherapy; MST, median survival time; OS, overall survival; LRF, Local failure rate.