Table 2. Cox model with hazard ratios and 95% confidence intervals of dementia associated with TCM and covariates among migraine patients.
| Variable | No. of events (n = 134) |
Crude* | Adjusted† | ||||
|---|---|---|---|---|---|---|---|
| HR | (95% CI) | P-value | HR | (95% CI) | P-value | ||
| TCM | |||||||
| No | 66 | 1.00 | reference | 1.00 | reference | ||
| Yes | 68 | 0.84 | (0.6–1.19) | 0.3277 | 0.65 | (0.46–0.92) | 0.0152 |
| Sex | |||||||
| Female | 67 | 1.00 | reference | 1.00 | reference | ||
| Male | 67 | 0.99 | (0.71–1.39) | 0.9656 | 0.78 | (0.55–1.11) | 0.1706 |
| Age group | |||||||
| 20–29 | 0 | - | - | - | - | - | - |
| 30–39 | 0 | - | - | - | - | - | - |
| 40–49 | 3 | 0.01 | (0–0.04) | < 0.0001 | 0.01 | (0–0.05) | < 0.0001 |
| 50–59 | 6 | 0.03 | (0.01–0.07) | < 0.0001 | 0.03 | (0.01–0.08) | < 0.0001 |
| 60–69 | 31 | 0.21 | (0.13–0.36) | < 0.0001 | 0.22 | (0.13–0.38) | < 0.0001 |
| 70–79 | 69 | 0.52 | (0.33–0.82) | 0.0054 | 0.55 | (0.35–0.88) | 0.0134 |
| ≥ 80 | 25 | 1.00 | reference | 1.00 | reference | ||
| Comorbidity (ref = no comorbidities) | |||||||
| Diabetes mellitus | 48 | 3.16 | (2.22–4.5) | < 0.0001 | 1.41 | (0.96–2.08) | 0.079 |
| Hypertension | 99 | 5.00 | (3.4–7.36) | < 0.0001 | 1.07 | (0.7–1.63) | 0.7617 |
| Coronary artery disease | 51 | 3.43 | (2.42–4.86) | < 0.0001 | 1.07 | (0.73–1.57) | 0.71 |
| Head injury | 7 | 1.15 | (0.54–2.46) | 0.7228 | 0.82 | (0.38–1.77) | 0.6118 |
| Depression | 23 | 2.85 | (1.82–4.47) | < 0.0001 | 2.43 | (1.52–3.89) | 0.0002 |
| Hyperlipidemia | 51 | 1.97 | (1.39–2.8) | 0.0001 | 0.88 | (0.6–1.3) | 0.5116 |
| Stroke | 66 | 4.29 | (3.06–6.02) | < 0.0001 | 1.24 | (0.86–1.78) | 0.2539 |
| Mental disorders | 0 | - | - | - | - | - | - |
| Chronic kidney disease | 6 | 2.32 | (1.02–5.27) | 0.0437 | 0.71 | (0.3–1.64) | 0.4191 |
| Renal dialysis | 0 | - | - | - | - | - | - |
Abbreviations: CI, confidence interval; HR, hazard ratio; TCM, traditional Chinese medicine.
Crude HR*represents the relative hazard ratio. Adjusted HR† represents the adjusted hazard ratio; mutually adjusted for TCM, age, sex, diabetes mellitus, hypertension, coronary artery disease, head injury, depression, hyperlipidemia, stroke, mental disorders, chronic kidney disease, and renal dialysis in the Cox proportional hazards regression.