B) At the end of follow-up (median 37 months, n = 315).

	Sensitivity	Specificity	PPV	NPV	Diagnostic accuracy
ATA	80,4	46,5	20,4	93,3	51,4
ETA	73,9	60,6	24,3	93,1	62,5
ATA after SPECT/CT	78,3	72,9	33,0	95,1	73,7
SPECT/CT	71,7	86,6**	47,8	94,7	84,4***
Risk at 1 year	100*	93,3**	71,9	100	94,3***

*No significant differences in sensitivities were found except in case of one-year reclassification (p < 0.01).

**Specificities of the individual parameters differed significantly, the one-year reclassification had the highest value (p < 0.01). The specificity of SPECT/CT was also significantly better than the values of the ATA and ETA risk classifications (p < 0.001).

***Diagnostic accuracy of one-year reclassification was excellent but not significantly better than that of SPECT/CT (p = 0.59). Both method provided better prediction than ATA, ETA and ATA after SPECT/CT classifications (p < 0.01).