Table 2. Pharmacokinetic parameters of methoxyamine.
| Dose | Half Life, mean (± SEM) | Cmax, mean (± SEM) | AUC, mean (± SEM) | Clearance, mean (± SEM) |
|---|---|---|---|---|
| (mg/m2) | (h) | (ng/mL) | (hng/mL) | (mL/h/m2) |
| 15 | 40.9 (± 7.0) | 12.6 (± 1.3) | 691.6 (± 44.8) | 22062.0 (± 1445.4) |
| 30 | 41.6 (± 8.9) | 18.8 (± 5.4) | 1044.4 (± 301.3) | 34241.2 (± 9978.7) |
| 60 | 44.9 (± 3.1) | 37.5 (± 8.3) | 2502.4 (± 816.3) | 29014.3 (± 7954.4) |
| 90 | 46.0 (± 5.9) | 100.0 (± 21.3) | 6560.6 (± 1560.1) | 16035.0 (± 4895.5) |
| 120 | 45.0 (± 5.2) | 100.4 (± 13.8) | 6358.2 (± 1042.2) | 22180.8 (± 4371.2) |
AUC: area under the curve of plasma concentration; Cmax: maximum plasma concentration.