Table 3. Adverse events in subjects treated with fludarabine and methoxyamine.
| Toxicity | All Grades (%) | Grade 3 – 4 (%) | ||
|---|---|---|---|---|
| Hematologic | N | % | N | % |
| Leukopenia | 17 | 85 | 10 | 50 |
| Neutropenia | 15 | 75 | 12 | 60 |
| Anemia | 20 | 100 | 8 | 40 |
| Thrombocytopenia | 13 | 65 | 5 | 25 |
| Lymphopenia | 16 | 80 | 14 | 70 |
| Gastrointestinal | ||||
| Anorexia | 10 | 50 | 0 | 0 |
| Constipation | 9 | 45 | 0 | 0 |
| Diarrhea | 5 | 25 | 1 | 5 |
| Nausea | 13 | 65 | 0 | 0 |
| Vomiting | 5 | 25 | 0 | 0 |
| Neurologic | ||||
| Insomnia | 7 | 35 | 1 | 5 |
| Dizziness | 2 | 10 | 0 | 0 |
| Paresthesias | 10 | 50 | 0 | 0 |
| Pain | 8 | 40 | 1 | 5 |
| Respiratory | ||||
| Cough | 2 | 10 | 0 | 0 |
| Dyspnea | 7 | 35 | 0 | 0 |
| General | ||||
| Fatigue | 17 | 85 | 0 | 0 |
| Cutaneous/Dermatologic | ||||
| Alopecia | 3 | 15 | 0 | 0 |
| Erythema | 2 | 10 | 0 | 0 |
| Pruritus | 2 | 10 | 0 | 0 |
| Infectious | ||||
| Fever | 6 | 30 | 1 | 5 |
| Infection | 5 | 25 | 3 | 15 |
| Cardiovascular | ||||
| Edema | 3 | 15 | 0 | 0 |
| Laboratory | ||||
| Hyperbilirubinemia | 8 | 40 | 0 | 0 |
| Hypokalemia | 3 | 15 | 0 | 0 |
| Hyperuricemia without TLS | 3 | 15 | 1 | 5 |
| Hypoalbuminemia | 7 | 35 | 1 | 5 |
| Hyponatremia | 8 | 40 | 0 | 0 |
| Hypocalcemia | 11 | 55 | 0 | 0 |
| Transaminase elevation | 5 | 25 | 1 | 5 |
| Creatinine elevation | 5 | 25 | 0 | 0 |
| Haptoglobin decrease | 6 | 30 | 0 | 0 |