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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Clin Cancer Res. 2017 Aug 1;23(21):6567–6579. doi: 10.1158/1078-0432.CCR-17-1574

Fig. 4. MEK inhibitors effectively suppress the phosphorylation of ERK, Bim and Mcl-1 accompanied with elevation of Bim and reduction of Mcl-1 in AZD9291-resistant NSCLC cells.

Fig. 4

The indicated cell lines were exposed to the tested agents alone or their combinations for 8 h and then harvested for preparation of whole-cell protein lysates and subsequent Western blotting to detect the given proteins. The concentrations used in A–C were 200 nM (AZD9291), 100 nM (AZD6244) and 25 nM (GSK1120212; GSK212), respectively. The concentrations used in D were 2 µM (AZD9291) and 100 nM (GSK212), respectively.