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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Cancer Res. 2017 Sep 18;77(21):5925–5937. doi: 10.1158/0008-5472.CAN-17-0604

Figure 6. Acquired resistance to nab-paclitaxel is associated with decrease in Cav-1 expression.

Figure 6

Nab-paclitaxel resistant cells were generated by chronic increasing exposure to nab-paclitaxel, such that resistant cell lines could readily grow in 50 and 100 nM of nab-paclitaxel. A–B. Cytotoxicity assays showing relative resistance of 100 nM resistant MIAPaCa-2 (A) and H23 (B) cells compared to control (parental) cells. (*p<0.05) C. Immunoblotting images demonstrate a decrease in Cav-1 expression in 50nM and 100nM nab-paclitaxel resistant MIAPaCa-2 and H23 cell lines compared to their respective parental (control) cell lines. D. MIAPaCa-2 and H23 control and resistant cell lines were pulsed with 0.5 mg/ml human albumin for 1 hr. Immunoblot showing a reduction in intracellular albumin uptake in the nab-paclitaxel resistant cell lines.