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. Author manuscript; available in PMC: 2018 Jul 4.
Published in final edited form as: Pigment Cell Melanoma Res. 2017 Jul 4;30(6):571–574. doi: 10.1111/pcmr.12603

Figure 1.

Figure 1

FBXW7 inactivation together with BrafV600E mutation cooperates in vivo to drive melanoma formation. (A) Survival curves of the mouse cohorts. Animals with tumor size greater than 1 cm3 or at 12 months after birth were euthanized. Log rank test was used for statistical analysis. (B) Representative examples of melanomas in the Tyr::CreERT2; BrafCA/CA; Fbxw7flox/flox mice are indicated. (C) Histology sections of the melanomas stained with hematoxylin and eosin (H&E) and immunohistochemistry for S100 and Ki67 are shown in the micrographs. (D) Tumors from Tyr::CreERT2; BrafCA/CA; Fbxw7flox/flox mice (without the overlying nevus cells and epidermis) were lysed and analyzed for MITF by western blotting. Actin was used as loading control.