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. Author manuscript; available in PMC: 2018 Jul 6.
Published in final edited form as: Mol Psychiatry. 2017 May 2;23(6):1394–1401. doi: 10.1038/mp.2017.99

Figure 1. S6K1 is required for the acquisition of extinction memory.

Figure 1

(A) S6K1 knockout mice display impairments in the acquisition of extinction compared to wild-type mice (n = 6 WT, n = 6 KO) (*p < 0.05, **p < 0.01). (B) PF-4708671 (50 mg/kg, i.p.) blocks the acquisition of extinction (*p < 0.05). (C) Left, representative blots for phosphorylated levels of ERK2, S6K1 (Ser421/Thr424), GluA1 (Thr840), S6K1 (Thr389), total protein levels and actin. (n= 6–9 box control, n = 7–9 extinction) Right, cumulative data for blots shown in (C). Data are represented as the mean ± SEM (*p< 0.05).