Figure 4. Inhibition of S6K1 attenuates neuronal activity in the basolateral nucleus of the amygdala during extinction.
(A) Representative GCaMP6s expression in the BLA. B) Mice that received PF-4708671 infusions were impaired in the acquisition of extinction (*p< 0.05) (n= 8 vehicle, n = 12 PF-4708671) C) Representative traces depicting tone-locked emitted fluorescence. Dashed red line depicts tone onset. (D) PF-4708671 blocks the increase in mean amplitude of calcium events during extinction (*p<0.05; ***p<0.001). Scale bars represent 50μm.