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. 2017 Nov 2;8:1268. doi: 10.1038/s41467-017-01347-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — a The pattern of distribution of disease profiles in mice according to the kind of inocula (brain, soluble infectivity or blood products). For each inoculum, the pattern of disease profiles observed in affected mice (numbers at the centre of each circle) is depicted in five categories grouped according to their status towards abnormal PrP: classical vCJD pattern (protease-resistant PrP^d, black), bulbospinal (BS) pattern (protease-resistant PrP^d, white-spotted black), spinal (S) profile (protease-sensitive PrP^d, grey) or cerebral involvement grouping cerebral (C), bulbar (B) profiles and animals with only neuronal lesions (NL) (no detectable PrP^d, white). The fifth category (grey-spotted white) corresponds to the non-vCJD mice (affected mice devoid of PrP^res but not sampled for histology. They might present either spinal profile or cerebral involvement). Below each circular panel are specified the percentage of transmission and the numbers of aging spinal animals (AS). b Two different putative pathophysiological pathways may occur depending on the aggregated or soluble nature of the initial infectivity