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. 2017 Nov 3;7:14597. doi: 10.1038/s41598-017-15058-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Response of arterial pressure (panel A), hindquarter blood flow (B), hindquarter vascular conductance (C), total renal blood flow (D), and renal vascular conductance (E) to a brief hypoxic challenge (inspiratory fraction of oxygen 10%). Data are percentage changes at the end of 100 s of hypoxia as related to the values recorded immediately before commencement of the hypoxia intervention (mean ± SEM, n = 9 for the saline group [control], n = 11 for the nitrite group); *denotes p < 0.05 control vs. nitrite group, x denotes p < 0.05 normoxia vs. hypoxia in the control group, +denotes p < 0.05 normoxia vs. hypoxia in the nitrite group.