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. 2017 Nov 2;7:14937. doi: 10.1038/s41598-017-14814-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Genome-wide expression profiling of HNSCC primary tumours (PT) and lymph node metastases (M) versus normal tissue (N). (A) Intrinsic gene set cluster analysis of 45 HNSCC samples. Unsupervised two-way hierarchical clustering and gene tree representation of differentially regulated genes (fold change ≥ 2.0 and p-value < 0.05) allows to separate N and PT. X-axis represents patient samples; y-axis represents the list of probe sets grouped by similarity using Pearson correlation. The comparison of PT versus N revealed 650 deregulated genes. (B–D) Differential expression of Taspase1 (B) and CDKN2A (C,D) in 15 HNSCC tumours. Whereas the protease Taspase1 is overexpressed in primary tumours, CDKN2A expression is significantly downregulated in most PT (p-value < 0.0001) as well as M compared to N (p-value < 0.05). Relative expression levels (log₂PT/N; log₂M/N) obtained by Affymetrix microarray analysis are shown. CDKN2A locus is represented by two probe sets as indicated.