Table 1.
Clinical characteristics of 13 adult-onset Still’s disease patients
| Characteristic | Patient | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age | 50.7 ± 17.6 | 40 | 59 | 21 | 69 | 39 | 67 | 38 | 30 | 78 | 48 | 47 | 50 | 74 |
| Sex | 61.5 of female | F | F | M | F | F | M | M | F | M | M | F | F | F |
| Clinical features | ||||||||||||||
| Fever | 76.9 | + | + | + | + | + | + | + | + | + | – | – | – | + |
| Sore throat | 15.4 | – | + | – | – | + | – | – | – | – | – | – | – | – |
| Skin rash | 30.8 | + | – | – | – | – | – | + | + | + | – | – | – | – |
| Lymphadenopathy | 69.2 | + | + | + | – | + | + | + | + | + | – | – | – | + |
| Hepatomegaly | 23.1 | – | – | + | – | – | + | – | + | – | – | – | – | – |
| Splenomegaly | 30.8 | – | – | + | – | + | + | – | + | – | – | – | – | – |
| Pericarditis | 30.8 | – | + | – | – | – | – | + | + | – | – | – | – | + |
| Pleuritis | 15.4 | – | + | – | – | – | – | – | – | – | – | – | – | + |
| Arthralgia | 61.5 | + | + | + | + | – | + | + | + | – | – | – | + | – |
| Laboratory findings | ||||||||||||||
| Leukocytes, × 103/µL | 13.2 ± 7.9 | 18.6 | 14.6 | 33.2 | 10.7 | 9 | 19.8 | 17.9 | 10.8 | 12.2 | 4.8 | 4.5 | 4.8 | 11.1 |
| Neutrophils, × 103/µL | 11.1 ± 7.9 | 16.5 | 13.3 | 32.6 | 9.4 | 6.8 | 12.7 | 15.8 | 8.5 | 10 | 2.9 | 2.6 | 2.9 | 10.5 |
| Hemoglobin, g/dL | 11.2 ± 1.8 | 10 | 8.5 | 11.4 | 11.6 | 12.5 | 11.6 | 12.1 | 8.9 | 11.8 | 14.6 | 13.3 | 10.4 | 9.1 |
| Platelets, × 103/µL | 259.5 ± 109 | 161 | 284 | 281 | 421 | 294 | 222 | 370 | 467 | 248 | 213 | 169 | 124 | 119 |
| AST, IU/L | 97.1 ± 138.6 | 47 | 14 | 38 | 405 | 41 | 32 | 29 | 36 | 178 | 19 | 24 | 15 | 384 |
| ALT, IU/L | 46.9 ± 43.8 | 42 | 16 | 16 | 152 | 37 | 41 | 41 | 19 | 86 | 19 | 15 | 12 | 114 |
| Ferritin, ng/mL | 14,361 ± 24,367 | 5,514 | 733 | 6,896 | 80,951 | 2,876 | 1,232 | 299 | 10,737 | 33,009 | 80 | 65 | 30 | 44,278 |
| ESR, mm/hr | 62.2 ± 35 | 55 | 120 | 64 | 60 | 89 | 105 | 93 | 85 | 34 | 12 | 18 | 18 | 55 |
| CRP, mg/dL | 11.3 ± 9.4 | 3.7 | 16.7 | 23 | 20.9 | 9.2 | 15.1 | 10.2 | 5.5 | 14.3 | 0.2 | 0 | 0 | 28.7 |
| Clinical score | 4.2 ± 2.4 | 4 | 6 | 6 | 3 | 6 | 6 | 5 | 7 | 4 | 0 | 0 | 1 | 6 |
| Disease activity | 76.9 | + | + | + | + | + | + | + | + | + | – | – | – | + |
Values are presented as mean ± SD or percentage. Clinical score was evaluated according to the method described by Pouchot et al. [3], which assigns a score from 0 to 12 and adds 1 point for each of the following manifestations: fever, typical rash, pleuritis, pneumonia, pericarditis, hepatomegaly or abnormal liver function tests, splenomegaly, lymphadenopathy, leukocytosis ≥ 15,000/mm2, sore throat, myalgia, and abdominal pain. Normal range of ESR, 0 to 25 mm/hr for females and 0 to 20 mm/hr for males; normal range of CRP, 0 to 0.3 mg/dL; normal range of ferritin, 13 to 150 ng/mL for females and 30 to 400 ng/mL for males. AST, aspartate transaminase; ALT, alanine transaminase; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein.