Table 2.

Between-group differences in the change in HbA1c for comparison of SU and SGLT2i as an add-on therapy to metformin [13]

Intervention	Trials	Duration, wk	No. of patients	HbA1c SGLT2i	HbA1c control	Change in HbA1c (mean difference)
Metformin + SGLT2i vs. Metformin + SU	Cefalu et al. (2013) [14]	104	1,452	7.8	7.8	–0.19 (–0.29 to –0.09)
	Nauck et al. (2011) [15]	208	814	7.7	7.7	–0.30 (–0.79 to 0.19)
	Ridderstrale et al. (2014) [16]	104	1,549	7.9	7.9	–0.11 (–0.19 to –0.03)
	Total					–0.15 (–0.21 to –0.08)

HbA1c, glycosylated hemoglobin; SU, sulfonylurea; SGLT2i, sodium-glucose cotransporter-2 inhibitor.